Kinase overexpressing cancers responsive to drug withdrawal
نویسندگان
چکیده
منابع مشابه
Kinase overexpressing cancers responsive to drug withdrawal
Aberrant protein kinase activity promotes tumor survival and proliferation, and targeted kinase inhibitors that halt growth and promote apoptosis demonstrate some cancers are truly kinase addicted. Clinically, this is best exemplified by chronic myeloid leukemia (CML), driven by the fusion kinase BCR-ABL, where tyrosine kinase inhibitor (TKI) therapy can control the disease for years, perhaps i...
متن کاملUse of dendritic cells to immunize against cancers overexpressing p53.
Immunizing patients against their tumors has obvious appeal. A successful vaccine would generate systemic immunity, contribute to the elimination of primary tumors, and, most importantly, eliminate metastatic foci, all with minimal side effects. Given the significant progress that has been made with regard to our understanding of the induction and regulation of immune responses, tumor vaccines ...
متن کاملExpression and Evaluation of HuscFv Antibody -PE40 Immunotoxin for Target Therapy of EGFR-Overexpressing Cancers
Background: Epidermal growth factor receptor (EGFR) plays an important role in the progression and tumorigenesis of the various cancers. In this regards, anti-EGFR antibodies are valuable approved therapeutics for the EGFR over-expressing cancers. However, the occurrence of mutations in the EGFR and/or KRAS genes; a common phenomenon which is seen in many cancers, lead to the r...
متن کاملNeonatal drug withdrawal.
Maternal use of certain drugs during pregnancy can result in transient neonatal signs consistent with withdrawal or acute toxicity or cause sustained signs consistent with a lasting drug effect. In addition, hospitalized infants who are treated with opioids or benzodiazepines to provide analgesia or sedation may be at risk for manifesting signs of withdrawal. This statement updates information ...
متن کاملNeonatal Drug Withdrawal
Symptoms of neonatal drug withdrawal consist of: W = wakefulness; I = irritability; T = tremulousness, temperature variation, tachypnea; H = hyeractivity, high-pitched persistent cry, hyperacusia, hyperreflexia, hypertonus; D = diarrhea, diaphoresis, disorganized suck; R = rub marks, respiratory distress, rhinorrhea; A = apneic attacks, autonomic dysfunction; W = weight loss or failure to gain ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Aging
سال: 2015
ISSN: 1945-4589
DOI: 10.18632/aging.100830